Program

Thursday, March 30^th

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18:15 Welcome address
Professor Antoniadis, President of the Hellenic Pasteur Institute

18:30 Keynote Lecture I
“Historical Introduction: “From Aristotle to Watson and Crick”
Professor Georges Cohen, Pasteur Institute, Paris

19:30 Keynote Lecture II
"What is the meaning of the genomic and post-genomic revolutions?”
Professor Michel Morange, Ecole Normale Supérieure, Paris

Friday, March 31^st

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Morning session I:
Introductive notes: FUNCTIONAL GENOMICS

9:30 Odile Ozier-Kalogeropoulos
Yeast Molecular Genetics, Pasteur Institute, Paris
“From Genetics to Genomics … and back: the yeast example”

10:45 Jean-Yves Coppée & Béatrice Regnault,
Platform DNA Arrays, Pasteur Institute Paris
“The Array technologies: practicalities and applications”
Overview of a DNA experiment
Affymetrix: GeneChip microarrays for human pathogens & disease

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Afternoon session

• Statistical Analysis I 14:30-15:30

Marie-Agnès Dillies,
“Introduction to basic statistics”

Group H : Practical course-1 16:00-18:30
Béatrice Regnault, José Osorio y Fortea, Diana Le Roux & Evie Melanitou
“Setting up transcriptome data files for analysis”

Group M : Workshop-I 16:00-18:30
Peter David & Geneviève Milon and J-Y. Coppée & Marie-Agnès Dillies
“Biology of Plasmodium (Data files available for microarray analysis”
Experimental design

Microorganisms

Saturday, April 2 ^nd

• Geneviève Milon & Peter David 9:00-10:15
  Molecular Immunology of Parasites, Pasteur Institute, Paris
  “Fever and chills in applying micro array technology to the study of Plasmodium"

• Evie Melanitou 10:30-11:30
  Molecular Medicine Department, Pasteur Institute, Paris
  “Functional Genomics in the understanding of complex hereditary diseases”

Poster Session 11:30-13:00
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Afternoon session

• Statistical Analysis II 14:30-15:30

Marie-Agnès Dillies
“Differential analysis of gene expression data-Microarray data normalization”

Group H : Workshop-I 16:00-18:30
Béatrice Regnault, José Osorio y Fortea, Diana Le Roux & Evie Melanitou
“How to set up a microarray experiment? Quality control of the data”

Group M : Practical course-1 16:00-18:30
J-Y. Coppée, Peter David, Geneviève Milon & Marie-Agnès Dillies
“Plasmodium falciparum transcriptome during the erythrocytic development: data loading, normalization and differential analysis”

Monday, April 3^rd

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Morning session III:
Array applications: 1. Gene expression and “Pathogen” diversity

• Carmen Buchrieser 9:00-10:15
  Genomics of Pathogens, Pasteur Institute, Paris
  “Advances in Legionella genomics: new insights into gene regulation, biodiversity and evolution”

• Hilde de Reuse 10:30-11:45
  Bacterial Pathogenesis of Mucus, Pasteur Institute, Paris
  "Functional and comparative genomics of the gastric “pathogen” Helicobacter pylori”

• Peter Ghazal 11:45-13:00
  Scottish Centre for Genomic Technology and Informatics (GTI), college of medicine, The Chancellor's Building, The University of Edinburgh, Scotland, UK
  “Pathway Biology: A systematic approach to analyzing high dimensional data”

Group M : Workshop-IIa 14:30-16:15
Carmen Buchrieser
“DNA arrays as a means to study biodiversity, and plasticity and evolution: common and different traits of bacterial genomes”
I. DNA/DNA hybridization

Group M : Workshop IIb 16:30-18:30
Hilde de Reuse
“DNA arrays as a means to study biodiversity, and plasticity and evolution: common and different traits of bacterial genomes”
II. Transcriptome analysis

Tuesday, April 4 ^th

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Morning session IV:
Arrays applications: 2. Deciphering disease pathways

• Christos (Kitsos) Louis 9:00-10:15
  IMBB-FORTH & Dept. Biol., University of. Crete, Heraklion, Crete , Greece
  "Sialomics and enteromics, or how to use insect genomics to fight vector borne diseases "

• Catherine Nguyen 10:30-11:45
  Cancer Institute of Marseille, INSERM, Marseille, France
  “ Transcriptome analysis to assess biological functions”

• Diana Le Roux 11:45-13:00
  Department of Radiobiology and Radiopathology, Commissariat à l'Energie Atomique, Evry Cedex , France "Dissecting the response of hematopoietic stem cells to ionizing radiation with microarrays"

• Statistical Analysis III 14:30-15:30
  Marie-Agnès Dillies
  “Unsupervised clustering”

Groupe H : Workshop-II 16:00-18:30
Catherine Nguyen
“Microarrays & Cancer”

 Groupe M : Practical course-2 16:00-18:30
Peter David, Geneviève Milon & J-Y Coppée, Marie-Agnès Dillies
“Plasmodium falciparum and the sickle cell trait: an example of how to extract biological relevant data (part I)”

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• Helen Parkinson 9:00-10:15
  European Bioinformatics Institute, EMBL-EBI Wellcome Trust Genome Campus, Hinxton UK
  "Building International Infrastructure for Microarray data storage and exchange"

• Stéphane Le Crom 10:30-11:45
  Ecole Normale Supérieure, Paris
  "Microarray data integration on a genomic platform”

• Group M & H 11:45-13:00
  Stéphane Le Crom
  “Cross-species comparison using expression data”

Afternoon session

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Group H 14:30-16:15
Helen Parkinson
“Workshop EMBL Submission”

Group H: Workshop-III 16:30-18:30
Diana Le Roux
“Ingenuity networks: How to integrate specific biological relationships foundational to human health and disease?”

Group M : Practical course-3 16:30-18:30
Peter David, Geneviève Milon & J-Y. Coppée, Marie-Agnès Dillies
“Plasmodium falciparum and the sickle cell trait: an example of how to extract biological relevant data (part II)”

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• Panagiotis Deloukas 9:00-10:15
  Wellcome Trust Sanger Institute, University of Oxford United Kingdom
  “Tools and resources for large scale disease association studies”

• Renata Grifantini 10:30-11:45
  Department of Bioinformatics and Cellular Microbiology, Chiron Vaccines, Siena , Italy
  "Impact of genomics on vaccine design: the experience of reverse vaccinology"

• George Tsagaris 11:45-13:00
  Genomics and Proteomics Research Unit Division of Biotechnology
  Foundation of Biomedical Research of the Academy of Athens
  "Toxicogenomics and Toxicoproteomics: current technologies and applications”

Group M 16:30-18:30
Helen Parkinson
“Workshop EMBL Submission”

• Meeting the Professor Session 19:00-20:00

General Discussion

Friday, April 7 ^th

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Morning session VII:
From Functional Genomics back to Biology

Closing Plenary Lecture I

• Geneviève Milon 9:00-10:15
  Immunophysiology and Intracellular Parasitism, Pasteur Institute, Paris
  “The impact of post -genomics on our understanding of parasitism: where do we stand?”

Closing Plenary Lecture II

• Stylianos Antonarakis 10:30-11:45
  Department of Genetic Medicine and Development, Geneva University Medical School , Geneva , Switzerland
  “Genomes, Evolution, and Human Disorders”

Conclusive Remarks 12:00

• Evie Melanitou & Penelope Mavromara

End of the course

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